Drug interactions
Dactinomycin + Doxorubicin
Severity: Moderate
Dactinomycin and Doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dactinomycin and doxorubicin both act as radiosensitizers, and combined use can provoke radiation recall reactions, including pneumonitis, in previously irradiated fields. Skin, mucosal and lung toxicity may be amplified.
What this interaction means in plain words
Dactinomycin and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dactinomycin belongs to Oncology; Doxorubicin belongs to Oncology.
Why it happens
Both drugs enhance radiation-induced tissue injury, with additive cytotoxicity.
What to do
Avoid concurrent radiotherapy or separate it from these agents where possible. Monitor for respiratory symptoms and manage recall pneumonitis with corticosteroids if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Dactinomycin
- Adenovirus types 4 and 7 live + Dactinomycin Contraindicated
- Belatacept + Dactinomycin Major
- Dactinomycin + Dengue vaccine Major
- Dactinomycin + Etrasimod Major
- Dactinomycin + Fingolimod Major
- Dactinomycin + Palifermin Major
Frequently asked questions
Can I take Dactinomycin with Doxorubicin?
MediHelp rates the interaction as moderate. Dactinomycin and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dactinomycin and doxorubicin both act as radiosensitizers, and combined use can provoke radiation recall reactions, including pneumonitis, in previously irradiated fields. Skin, mucosal and lung toxicity may be amplified.
How serious is the interaction between Dactinomycin and Doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent radiotherapy or separate it from these agents where possible. Monitor for respiratory symptoms and manage recall pneumonitis with corticosteroids if it occurs.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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