Drug interactions
Dactinomycin + Influenza virus vaccine trivalent adjuvanted
Severity: Moderate
Dactinomycin and Influenza virus vaccine trivalent adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic chemotherapy can blunt the antibody response to inactivated influenza vaccine, so protection may be lower than expected. The vaccine is not live and is not itself dangerous in this setting, and vaccination is generally still recommended for patients on chemotherapy.
What this interaction means in plain words
Dactinomycin and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced myelosuppression and lymphocyte depletion reduce the humoral response to vaccination.
What to do
Where the treatment schedule allows, vaccinate before starting chemotherapy or between cycles when counts have recovered. Do not withhold vaccination in patients who need it, and consider the possibility of reduced protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dactinomycin
- Adenovirus types 4 and 7 live + Dactinomycin Contraindicated
- Belatacept + Dactinomycin Major
- Dactinomycin + Dengue vaccine Major
- Dactinomycin + Etrasimod Major
- Dactinomycin + Fingolimod Major
- Dactinomycin + Palifermin Major
Frequently asked questions
Can I take Dactinomycin with Influenza virus vaccine trivalent adjuvanted?
MediHelp rates the interaction as moderate. Dactinomycin and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytotoxic chemotherapy can blunt the antibody response to inactivated influenza vaccine, so protection may be lower than expected. The vaccine is not live and is not itself dangerous in this setting, and vaccination is generally still recommended for patients on chemotherapy.
How serious is the interaction between Dactinomycin and Influenza virus vaccine trivalent adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where the treatment schedule allows, vaccinate before starting chemotherapy or between cycles when counts have recovered. Do not withhold vaccination in patients who need it, and consider the possibility of reduced protection.
What other medicines interact with Dactinomycin?
MediHelp also lists interactions of Dactinomycin with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Dactinomycin page.
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