Drug interactions
Dactinomycin + Meningococcal group b vaccine
Severity: Moderate
Dactinomycin and Meningococcal group b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy may blunt antibody responses to this non-live vaccine, so the patient may be less protected than expected.
What this interaction means in plain words
Dactinomycin and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic therapy suppresses lymphocyte function and antibody production.
What to do
Vaccinate before chemotherapy when feasible, or after immune recovery. Consider revaccination if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dactinomycin
- Adenovirus types 4 and 7 live + Dactinomycin Contraindicated
- Belatacept + Dactinomycin Major
- Dactinomycin + Dengue vaccine Major
- Dactinomycin + Etrasimod Major
- Dactinomycin + Fingolimod Major
- Dactinomycin + Palifermin Major
Frequently asked questions
Can I take Dactinomycin with Meningococcal group b vaccine?
MediHelp rates the interaction as moderate. Dactinomycin and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy may blunt antibody responses to this non-live vaccine, so the patient may be less protected than expected.
How serious is the interaction between Dactinomycin and Meningococcal group b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before chemotherapy when feasible, or after immune recovery. Consider revaccination if given during treatment.
What other medicines interact with Dactinomycin?
MediHelp also lists interactions of Dactinomycin with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Dactinomycin page.
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