Drug interactions
Dactinomycin + Olaparib
Severity: Moderate
Dactinomycin and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow function, and dactinomycin also damages DNA. Used together they can deepen and prolong anemia, neutropenia and thrombocytopenia beyond what either drug causes alone.
What this interaction means in plain words
Dactinomycin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dactinomycin belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive pharmacodynamic myelosuppression from a DNA-damaging cytotoxic combined with a PARP inhibitor.
What to do
Monitor complete blood counts frequently during combined treatment. Delay cycles or reduce doses of either drug if significant cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dactinomycin
- Adenovirus types 4 and 7 live + Dactinomycin Contraindicated
- Belatacept + Dactinomycin Major
- Dactinomycin + Dengue vaccine Major
- Dactinomycin + Etrasimod Major
- Dactinomycin + Fingolimod Major
- Dactinomycin + Palifermin Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Dactinomycin with Olaparib?
MediHelp rates the interaction as moderate. Dactinomycin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow function, and dactinomycin also damages DNA. Used together they can deepen and prolong anemia, neutropenia and thrombocytopenia beyond what either drug causes alone.
How serious is the interaction between Dactinomycin and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently during combined treatment. Delay cycles or reduce doses of either drug if significant cytopenias develop.
What other medicines interact with Dactinomycin?
MediHelp also lists interactions of Dactinomycin with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Dactinomycin page.
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