Drug interactions
Dalfampridine + Dapagliflozin-metformin
Severity: Moderate
Dalfampridine and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both metformin and dalfampridine are cleared by renal OCT2 secretion, so co-administration could theoretically increase exposure to either drug. Higher dalfampridine levels raise seizure risk, and higher metformin levels raise the risk of adverse effects.
What this interaction means in plain words
Dalfampridine and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalfampridine belongs to Central Nervous System; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Competition for OCT2-mediated renal tubular secretion.
What to do
Monitor for dalfampridine-related adverse effects including seizures, and for metformin toxicity. Check renal function before and during combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Dalfampridine
- Dalfampridine + Trilaciclib Major
- Alogliptin-metformin + Dalfampridine Moderate
- Canagliflozin-metformin + Dalfampridine Moderate
- Dalfampridine + Dolutegravir Moderate
- Dalfampridine + Empagliflozin-metformin Moderate
- Dalfampridine + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dalfampridine with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Dalfampridine and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both metformin and dalfampridine are cleared by renal OCT2 secretion, so co-administration could theoretically increase exposure to either drug. Higher dalfampridine levels raise seizure risk, and higher metformin levels raise the risk of adverse effects.
How serious is the interaction between Dalfampridine and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dalfampridine-related adverse effects including seizures, and for metformin toxicity. Check renal function before and during combined use.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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