Drug interactions
Dalteparin + Ketorolac
Severity: Contraindicated
Dalteparin and Ketorolac: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac impairs platelet function and can cause GI bleeding, and dalteparin is an anticoagulant, so serious hemorrhage risk increases, including spinal or epidural hematoma around neuraxial procedures. Ketorolac labeling contraindicates use in patients at risk of bleeding.
What this interaction means in plain words
Dalteparin and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dalteparin belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment through antiplatelet NSAID effect and factor Xa inhibition by low molecular weight heparin.
What to do
Avoid ketorolac in patients on dalteparin and select a non-NSAID analgesic; if exposure occurs, monitor for bleeding signs and hemoglobin.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
- Acetylsalicylic acid + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Ketorolac?
MediHelp rates the interaction as contraindicated. Dalteparin and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac impairs platelet function and can cause GI bleeding, and dalteparin is an anticoagulant, so serious hemorrhage risk increases, including spinal or epidural hematoma around neuraxial procedures. Ketorolac labeling contraindicates use in patients at risk of bleeding.
How serious is the interaction between Dalteparin and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients on dalteparin and select a non-NSAID analgesic; if exposure occurs, monitor for bleeding signs and hemoglobin.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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