Drug reference
dalteparin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Thrombotics)
Mechanism of action
LMW heparin with antithrombotic properties; enhances inhibition of Factor Xa & thrombin by antithrombin, minimal effect on APTT
Common side effects
- Injection site pain
- Increased liver function test
- Injection site hematoma
- Thrombocytopenia
- Major hemorrhage
Boxed warnings
- Epidural or spinal hematomas may occur in patients anticoagulated with LMWH or heparinoids who receive neuraxial (epidural/spinal) anesthesia or spinal puncture These hematomas may result in long-term or permanent paralysis Patients should be frequently monitored for signs and symptoms of neurologic impairment; if neurological compromise noted, urgent treatment necessary Optimal timing between the administration of dalteparin and neuraxial procedures is not known Physicians should consider the benefits versus risk before neuraxial intervention in patients anticoagulated or to be a…
Contraindications
- Hypersensitivity to dalteparin, heparin or pork products Active major bleeding, thrombocytopenia associated with antiplatelet antibodies History of heparin-induced thrombocytopenia or heparin-induced thrombocytopenia with thrombosis Patients undergoing epidural/neuraxial anesthesia, as a t…
Known interactions (11)
- dalteparin + mifepristone Contraindicated
- abciximab + dalteparin Major
- bazedoxifene-conjugated estrogens + dalteparin Major
- cilostazol + dalteparin Major
- clopidogrel + dalteparin Major
- dalteparin + eptifibatide Major
- dalteparin + ticlopidine Major
- dalteparin + tirofiban Major
- anagrelide + dalteparin Moderate
- dalteparin + dipyridamole Moderate
- dalteparin + estradiol Moderate
Related conditions
Frequently asked questions
What drug class is dalteparin?
dalteparin belongs to: Cardiovascular.
How does dalteparin work?
LMW heparin with antithrombotic properties; enhances inhibition of Factor Xa & thrombin by antithrombin, minimal effect on APTT
What are the common side effects of dalteparin?
Injection site pain, Increased liver function test, Injection site hematoma, Thrombocytopenia, Major hemorrhage
Which drugs interact with dalteparin?
mifepristone, abciximab, bazedoxifene-conjugated estrogens, cilostazol, clopidogrel, eptifibatide, ticlopidine, tirofiban, anagrelide, dipyridamole, estradiol
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