Drug interactions
Danazol + Dapagliflozin-metformin
Severity: Moderate
Danazol and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can cause insulin resistance and impair glucose tolerance, which may reduce the effect of antidiabetic drugs. Glycemic control may worsen during treatment.
What this interaction means in plain words
Danazol and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic effects of danazol reduce insulin sensitivity and glucose tolerance, opposing metformin and dapagliflozin.
What to do
Monitor blood glucose and HbA1c when danazol is started, and increase antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Danazol with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Danazol and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol can cause insulin resistance and impair glucose tolerance, which may reduce the effect of antidiabetic drugs. Glycemic control may worsen during treatment.
How serious is the interaction between Danazol and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when danazol is started, and increase antidiabetic therapy if control worsens.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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