Drug interactions
Danazol + Dutasteride-tamsulosin
Severity: Moderate
Danazol and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and can raise tamsulosin and dutasteride concentrations. Greater alpha-blocker effects such as hypotension and dizziness may result.
What this interaction means in plain words
Danazol and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of tamsulosin and dutasteride.
What to do
Monitor for orthostatic hypotension and dizziness during combined therapy. Reduce tamsulosin dose if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Frequently asked questions
Can I take Danazol with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Danazol and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and can raise tamsulosin and dutasteride concentrations. Greater alpha-blocker effects such as hypotension and dizziness may result.
How serious is the interaction between Danazol and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and dizziness during combined therapy. Reduce tamsulosin dose if symptoms develop.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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