Drug interactions
Danazol + Fluticasone-vilanterol
Severity: Minor
Danazol and Fluticasone-vilanterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and may slightly increase exposure to fluticasone furoate and vilanterol. The clinical significance is likely small with inhaled dosing.
What this interaction means in plain words
Danazol and Fluticasone-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol weakly inhibits CYP3A4-mediated metabolism of the inhaled drugs.
What to do
No dose adjustment is usually needed; be alert for tachycardia, tremor or steroid-related adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Danazol with Fluticasone-vilanterol?
MediHelp rates the interaction as minor. Danazol and Fluticasone-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and may slightly increase exposure to fluticasone furoate and vilanterol. The clinical significance is likely small with inhaled dosing.
How serious is the interaction between Danazol and Fluticasone-vilanterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; be alert for tachycardia, tremor or steroid-related adverse effects.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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