Drug interactions
Danazol + Fluticasone
Severity: Minor
Danazol and Fluticasone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may raise fluticasone concentrations. Higher systemic exposure could lead to corticosteroid adverse effects such as adrenal suppression, particularly with prolonged use.
What this interaction means in plain words
Danazol and Fluticasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of fluticasone.
What to do
Monitor for systemic corticosteroid effects during prolonged co-use. Use the lowest effective fluticasone dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone
Frequently asked questions
Can I take Danazol with Fluticasone?
MediHelp rates the interaction as minor. Danazol and Fluticasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a CYP3A4 inhibitor and may raise fluticasone concentrations. Higher systemic exposure could lead to corticosteroid adverse effects such as adrenal suppression, particularly with prolonged use.
How serious is the interaction between Danazol and Fluticasone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid effects during prolonged co-use. Use the lowest effective fluticasone dose.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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