Drug interactions
Fluticasone + Fosamprenavir
Severity: Major
Fluticasone and Fosamprenavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (amprenavir), often boosted with ritonavir, inhibits CYP3A4 and can increase fluticasone exposure. Systemic corticosteroid toxicity may result with prolonged use.
What this interaction means in plain words
Fluticasone and Fosamprenavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Amprenavir, the active metabolite, inhibits CYP3A4, reducing fluticasone metabolism.
What to do
Use an alternative corticosteroid such as beclomethasone for long-term therapy. If combined, monitor for Cushingoid signs and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone
Frequently asked questions
Can I take Fluticasone with Fosamprenavir?
MediHelp rates the interaction as major. Fluticasone and Fosamprenavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosamprenavir (amprenavir), often boosted with ritonavir, inhibits CYP3A4 and can increase fluticasone exposure. Systemic corticosteroid toxicity may result with prolonged use.
How serious is the interaction between Fluticasone and Fosamprenavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative corticosteroid such as beclomethasone for long-term therapy. If combined, monitor for Cushingoid signs and adrenal suppression.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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