Drug interactions
Atazanavir + Fluticasone
Severity: Major
Atazanavir and Fluticasone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir, especially when boosted with ritonavir or cobicistat, inhibits CYP3A4 and can raise fluticasone levels. Cushing syndrome and adrenal suppression have been described with this type of combination.
What this interaction means in plain words
Atazanavir and Fluticasone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Fluticasone belongs to Respiratory.
Why it happens
Atazanavir inhibits CYP3A4, reducing systemic clearance of fluticasone.
What to do
Prefer beclomethasone or another steroid less dependent on CYP3A4, particularly for long-term use. If combined, monitor for Cushingoid signs and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Fluticasone?
MediHelp rates the interaction as major. Atazanavir and Fluticasone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir, especially when boosted with ritonavir or cobicistat, inhibits CYP3A4 and can raise fluticasone levels. Cushing syndrome and adrenal suppression have been described with this type of combination.
How serious is the interaction between Atazanavir and Fluticasone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer beclomethasone or another steroid less dependent on CYP3A4, particularly for long-term use. If combined, monitor for Cushingoid signs and adrenal suppression.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Clarithromycin, Cobicistat, Darunavir. The full list is on the Fluticasone page.
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