Drug interactions
Danazol + Glimepiride
Severity: Moderate
Danazol and Glimepiride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is an androgenic agent that can impair glucose tolerance and insulin sensitivity, which may alter glycemic control in patients taking glimepiride. The direction of effect is variable, and either hyper- or hypoglycemia may occur.
What this interaction means in plain words
Danazol and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic effects alter insulin sensitivity and glucose handling, producing unpredictable pharmacodynamic changes in glucose control.
What to do
Monitor blood glucose more frequently when danazol is started or stopped. Adjust the glimepiride dose according to results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Danazol and Glimepiride, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Glimepiride
Frequently asked questions
Can I take Danazol with Glimepiride?
MediHelp rates the interaction as moderate. Danazol and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is an androgenic agent that can impair glucose tolerance and insulin sensitivity, which may alter glycemic control in patients taking glimepiride. The direction of effect is variable, and either hyper- or hypoglycemia may occur.
How serious is the interaction between Danazol and Glimepiride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when danazol is started or stopped. Adjust the glimepiride dose according to results.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
