Drug interactions
Danazol + Glyburide
Severity: Moderate
Danazol and Glyburide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is an androgen derivative that can cause insulin resistance and impaired glucose tolerance, which may reduce the glucose-lowering effect of glyburide. Glycemic control may deteriorate when danazol is started, and hypoglycemia risk may rise when it is stopped.
What this interaction means in plain words
Danazol and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic effects of danazol induce insulin resistance and glucose intolerance, opposing sulfonylurea action.
What to do
Monitor blood glucose when danazol is started, changed or stopped. Adjust the glyburide dose according to readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Danazol and Glyburide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Danazol with Glyburide?
MediHelp rates the interaction as moderate. Danazol and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is an androgen derivative that can cause insulin resistance and impaired glucose tolerance, which may reduce the glucose-lowering effect of glyburide. Glycemic control may deteriorate when danazol is started, and hypoglycemia risk may rise when it is stopped.
How serious is the interaction between Danazol and Glyburide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started, changed or stopped. Adjust the glyburide dose according to readings.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
