Drug interactions
Danazol + Linagliptin-metformin
Severity: Minor
Danazol and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can impair glucose tolerance and cause insulin resistance, which may worsen glycemic control on metformin and linagliptin. It is also a weak CYP3A4 inhibitor, but this has little relevance for linagliptin.
What this interaction means in plain words
Danazol and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Androgenic effects reduce insulin sensitivity, and weak CYP3A4 inhibition may slightly raise linagliptin levels.
What to do
Monitor blood glucose when danazol is started or stopped and adjust the antidiabetic regimen if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Danazol with Linagliptin-metformin?
MediHelp rates the interaction as minor. Danazol and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol can impair glucose tolerance and cause insulin resistance, which may worsen glycemic control on metformin and linagliptin. It is also a weak CYP3A4 inhibitor, but this has little relevance for linagliptin.
How serious is the interaction between Danazol and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started or stopped and adjust the antidiabetic regimen if needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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