Drug interactions
Danazol + Nicardipine
Severity: Moderate
Danazol and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may raise nicardipine concentrations. This can cause excessive hypotension, reflex tachycardia, headache, flushing and peripheral edema.
What this interaction means in plain words
Danazol and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of nicardipine.
What to do
Monitor blood pressure and heart rate when starting or stopping danazol, and reduce the nicardipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Danazol with Nicardipine?
MediHelp rates the interaction as moderate. Danazol and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may raise nicardipine concentrations. This can cause excessive hypotension, reflex tachycardia, headache, flushing and peripheral edema.
How serious is the interaction between Danazol and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping danazol, and reduce the nicardipine dose if hypotension or edema develops.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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