Drug interactions
Danazol + Quinidine
Severity: Moderate
Danazol and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and can raise quinidine concentrations. Because of quinidine's narrow therapeutic index, this raises the risk of QT prolongation and arrhythmia.
What this interaction means in plain words
Danazol and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of quinidine.
What to do
Monitor quinidine levels and ECG QTc, reducing the quinidine dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Danazol with Quinidine?
MediHelp rates the interaction as moderate. Danazol and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and can raise quinidine concentrations. Because of quinidine's narrow therapeutic index, this raises the risk of QT prolongation and arrhythmia.
How serious is the interaction between Danazol and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor quinidine levels and ECG QTc, reducing the quinidine dose if levels rise.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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