Drug interactions
Danazol + Regorafenib
Severity: Minor
Danazol and Regorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and could raise regorafenib exposure modestly. This is unlikely to be significant, but regorafenib has dose-related hepatotoxicity, hand-foot skin reaction and hypertension.
What this interaction means in plain words
Danazol and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP3A4-mediated regorafenib metabolism by danazol.
What to do
No empirical dose change; monitor liver function tests and blood pressure, and reduce regorafenib dose per label if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Danazol and Regorafenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Regorafenib
Frequently asked questions
Can I take Danazol with Regorafenib?
MediHelp rates the interaction as minor. Danazol and Regorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and could raise regorafenib exposure modestly. This is unlikely to be significant, but regorafenib has dose-related hepatotoxicity, hand-foot skin reaction and hypertension.
How serious is the interaction between Danazol and Regorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; monitor liver function tests and blood pressure, and reduce regorafenib dose per label if toxicity occurs.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
