Drug interactions
Atazanavir + Regorafenib
Severity: Major
Atazanavir and Regorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor and may raise regorafenib concentrations while reducing active metabolite formation. The net effect on safety and efficacy is unpredictable and may increase toxicity such as hepatotoxicity.
What this interaction means in plain words
Atazanavir and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Regorafenib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition reduces regorafenib metabolism.
What to do
Avoid concomitant use of strong CYP3A4 inhibitors with regorafenib. Choose an alternative antiretroviral, or monitor liver function and tolerability closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Regorafenib
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Regorafenib?
MediHelp rates the interaction as major. Atazanavir and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a strong CYP3A4 inhibitor and may raise regorafenib concentrations while reducing active metabolite formation. The net effect on safety and efficacy is unpredictable and may increase toxicity such as hepatotoxicity.
How serious is the interaction between Atazanavir and Regorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of strong CYP3A4 inhibitors with regorafenib. Choose an alternative antiretroviral, or monitor liver function and tolerability closely.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Carbamazepine, Clarithromycin. The full list is on the Regorafenib page.
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