Drug interactions
Danazol + Repaglinide
Severity: Moderate
Danazol and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can cause insulin resistance and impair glucose tolerance, which may reduce the effect of repaglinide. It is also a weak CYP3A4 inhibitor and could modestly raise repaglinide levels, so the net effect on glucose is unpredictable.
What this interaction means in plain words
Danazol and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic induction of insulin resistance, plus weak CYP3A4 inhibition affecting repaglinide metabolism.
What to do
Monitor blood glucose when danazol is started or stopped and adjust the repaglinide dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Danazol with Repaglinide?
MediHelp rates the interaction as moderate. Danazol and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol can cause insulin resistance and impair glucose tolerance, which may reduce the effect of repaglinide. It is also a weak CYP3A4 inhibitor and could modestly raise repaglinide levels, so the net effect on glucose is unpredictable.
How serious is the interaction between Danazol and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started or stopped and adjust the repaglinide dose accordingly.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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