Drug interactions
Danazol + Saxagliptin-metformin
Severity: Moderate
Danazol and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can cause insulin resistance and impair glucose tolerance, which may reduce glycemic control on saxagliptin and metformin. It is also a CYP3A4 inhibitor that may modestly raise saxagliptin levels.
What this interaction means in plain words
Danazol and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic effects of danazol induce insulin resistance, and weak CYP3A4 inhibition may raise saxagliptin concentrations.
What to do
Monitor blood glucose during danazol therapy and adjust antidiabetic doses as needed. Consider a lower saxagliptin dose only if a strong CYP3A4 inhibitor effect is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Danazol with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Danazol and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol can cause insulin resistance and impair glucose tolerance, which may reduce glycemic control on saxagliptin and metformin. It is also a CYP3A4 inhibitor that may modestly raise saxagliptin levels.
How serious is the interaction between Danazol and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during danazol therapy and adjust antidiabetic doses as needed. Consider a lower saxagliptin dose only if a strong CYP3A4 inhibitor effect is suspected.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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