Drug interactions
Danazol + Sitagliptin
Severity: Minor
Danazol and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol, an androgenic agent, can cause insulin resistance and glucose intolerance, so it would be expected to worsen glycemic control rather than enhance sitagliptin. The effect on diabetes control is variable and may require attention in patients on antidiabetic therapy.
What this interaction means in plain words
Danazol and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Androgenic effects of danazol may alter insulin sensitivity and glucose metabolism; the direction and magnitude are not well established.
What to do
Monitor blood glucose when danazol is started or stopped and adjust antidiabetic therapy according to results.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Danazol with Sitagliptin?
MediHelp rates the interaction as minor. Danazol and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol, an androgenic agent, can cause insulin resistance and glucose intolerance, so it would be expected to worsen glycemic control rather than enhance sitagliptin. The effect on diabetes control is variable and may require attention in patients on antidiabetic therapy.
How serious is the interaction between Danazol and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started or stopped and adjust antidiabetic therapy according to results.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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