Drug interactions
Danazol + Tolazamide
Severity: Moderate
Danazol and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can impair glucose tolerance and cause insulin resistance, which may alter diabetes control in patients taking tolazamide. Changes in glycemic control, usually hyperglycemia, can occur.
What this interaction means in plain words
Danazol and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic effects of danazol cause insulin resistance and altered glucose metabolism, opposing or confusing sulfonylurea effects.
What to do
Monitor blood glucose closely when danazol is started or stopped. Adjust the tolazamide dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Danazol with Tolazamide?
MediHelp rates the interaction as moderate. Danazol and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol can impair glucose tolerance and cause insulin resistance, which may alter diabetes control in patients taking tolazamide. Changes in glycemic control, usually hyperglycemia, can occur.
How serious is the interaction between Danazol and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when danazol is started or stopped. Adjust the tolazamide dose accordingly.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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