Drug interactions
Danazol + Tolbutamide
Severity: Minor
Danazol and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is an androgenic steroid that can alter glucose tolerance and insulin sensitivity. In patients taking tolbutamide, glycemic control may change unpredictably, and some reports describe a hypoglycemic potentiation with anabolic or androgenic steroids. Clinical significance is usually modest.
What this interaction means in plain words
Danazol and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Androgenic steroids may alter insulin sensitivity and glucose handling, producing variable additive effects on glycemia; the exact mechanism is not firmly established.
What to do
Monitor blood glucose when danazol is started or stopped and adjust the tolbutamide dose if glycemic control shifts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Danazol and Tolbutamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Danazol with Tolbutamide?
MediHelp rates the interaction as minor. Danazol and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is an androgenic steroid that can alter glucose tolerance and insulin sensitivity. In patients taking tolbutamide, glycemic control may change unpredictably, and some reports describe a hypoglycemic potentiation with anabolic or androgenic steroids. Clinical significance is usually modest.
How serious is the interaction between Danazol and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started or stopped and adjust the tolbutamide dose if glycemic control shifts.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
