Drug interactions
Danazol + Verapamil
Severity: Moderate
Danazol and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can increase verapamil concentrations, which may lead to excessive blood pressure lowering, bradycardia or AV block. The effect is predicted from CYP3A4 inhibition and is usually manageable.
What this interaction means in plain words
Danazol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4, reducing verapamil metabolism.
What to do
Monitor heart rate, blood pressure and PR interval after starting danazol and lower the verapamil dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Danazol with Verapamil?
MediHelp rates the interaction as moderate. Danazol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol can increase verapamil concentrations, which may lead to excessive blood pressure lowering, bradycardia or AV block. The effect is predicted from CYP3A4 inhibition and is usually manageable.
How serious is the interaction between Danazol and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and PR interval after starting danazol and lower the verapamil dose if bradycardia or hypotension occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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