Drug interactions
Danazol + Warfarin
Severity: Major
Danazol and Warfarin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can markedly increase warfarin's anticoagulant effect and INR, with reported serious bleeding.
What this interaction means in plain words
Danazol and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Danazol reduces clotting factor synthesis and may inhibit warfarin metabolism, enhancing anticoagulation.
What to do
Check INR frequently when starting, stopping or changing danazol and reduce warfarin dose as needed. Consider alternatives to danazol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Danazol with Warfarin?
MediHelp rates the interaction as major. Danazol and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Danazol can markedly increase warfarin's anticoagulant effect and INR, with reported serious bleeding.
How serious is the interaction between Danazol and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR frequently when starting, stopping or changing danazol and reduce warfarin dose as needed. Consider alternatives to danazol.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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