Drug interactions
Danshen + Diflunisal
Severity: Moderate
Danshen and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danshen has antiplatelet and anticoagulant-like activity and has been associated with raised INR in patients taking warfarin. Combined with diflunisal, which inhibits platelet function and irritates the GI mucosa, bleeding risk may be increased.
What this interaction means in plain words
Danshen and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on platelet function and coagulation, with NSAID-related mucosal injury.
What to do
Avoid the combination where possible, and counsel patients to report bruising, black stools or other bleeding. Monitor closely if anticoagulants are also used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Danshen with Diflunisal?
MediHelp rates the interaction as moderate. Danshen and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danshen has antiplatelet and anticoagulant-like activity and has been associated with raised INR in patients taking warfarin. Combined with diflunisal, which inhibits platelet function and irritates the GI mucosa, bleeding risk may be increased.
How serious is the interaction between Danshen and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and counsel patients to report bruising, black stools or other bleeding. Monitor closely if anticoagulants are also used.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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