Drug interactions
Danshen + Etodolac
Severity: Moderate
Danshen and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danshen (Salvia miltiorrhiza) has antiplatelet and anticoagulant-like activity and has been associated with increased INR with warfarin. With etodolac, bleeding risk may be increased.
What this interaction means in plain words
Danshen and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effect from COX inhibition and danshen's inhibition of platelet aggregation.
What to do
Advise patients to avoid danshen while on NSAIDs, especially with other antithrombotic drugs. Monitor for bruising and gastrointestinal bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Danshen with Etodolac?
MediHelp rates the interaction as moderate. Danshen and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danshen (Salvia miltiorrhiza) has antiplatelet and anticoagulant-like activity and has been associated with increased INR with warfarin. With etodolac, bleeding risk may be increased.
How serious is the interaction between Danshen and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid danshen while on NSAIDs, especially with other antithrombotic drugs. Monitor for bruising and gastrointestinal bleeding.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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