Drug interactions
Danshen + Indomethacin
Severity: Moderate
Danshen and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danshen has antiplatelet and possible anticoagulant activity and indomethacin impairs platelet function and irritates the gastric mucosa. Together they may raise bleeding risk, including GI bleeding.
What this interaction means in plain words
Danshen and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet and bleeding-promoting effects; danshen may also potentiate anticoagulant action.
What to do
Avoid combining where possible, especially in patients on anticoagulants. If used together, monitor for bleeding signs and consider GI protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Danshen with Indomethacin?
MediHelp rates the interaction as moderate. Danshen and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danshen has antiplatelet and possible anticoagulant activity and indomethacin impairs platelet function and irritates the gastric mucosa. Together they may raise bleeding risk, including GI bleeding.
How serious is the interaction between Danshen and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially in patients on anticoagulants. If used together, monitor for bleeding signs and consider GI protection.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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