Drug interactions
Danshen + Ketoprofen
Severity: Moderate
Danshen and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danshen has antiplatelet and anticoagulant-like activity and ketoprofen inhibits platelet function and irritates the gastric mucosa. Combined use may increase the risk of bruising and bleeding, including gastrointestinal bleeding.
What this interaction means in plain words
Danshen and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on platelet function and coagulation (NSAID COX inhibition plus herbal antiplatelet activity).
What to do
Avoid combining where possible, particularly in patients also taking anticoagulants; if used, monitor for bleeding signs and stop danshen before procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Danshen with Ketoprofen?
MediHelp rates the interaction as moderate. Danshen and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danshen has antiplatelet and anticoagulant-like activity and ketoprofen inhibits platelet function and irritates the gastric mucosa. Combined use may increase the risk of bruising and bleeding, including gastrointestinal bleeding.
How serious is the interaction between Danshen and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, particularly in patients also taking anticoagulants; if used, monitor for bleeding signs and stop danshen before procedures.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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