Drug interactions
Danshen + Oxaprozin
Severity: Moderate
Danshen and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danshen (Salvia miltiorrhiza) has antiplatelet and anticoagulant-like activity and may add to the bleeding risk of an NSAID. Evidence consists mostly of case reports with warfarin and pharmacologic extrapolation.
What this interaction means in plain words
Danshen and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of hemostasis: NSAID platelet inhibition and GI mucosal injury plus the antiplatelet effects of danshen.
What to do
Advise patients to avoid danshen while taking oxaprozin, and monitor for bruising, GI bleeding or melena if they use it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Danshen with Oxaprozin?
MediHelp rates the interaction as moderate. Danshen and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danshen (Salvia miltiorrhiza) has antiplatelet and anticoagulant-like activity and may add to the bleeding risk of an NSAID. Evidence consists mostly of case reports with warfarin and pharmacologic extrapolation.
How serious is the interaction between Danshen and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid danshen while taking oxaprozin, and monitor for bruising, GI bleeding or melena if they use it.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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