Drug interactions
Danshen + Sulindac
Severity: Moderate
Danshen and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danshen (Salvia miltiorrhiza) has antiplatelet activity and has been reported to potentiate warfarin. With an NSAID there may be an additive bleeding tendency.
What this interaction means in plain words
Danshen and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects from danshen constituents and NSAID cyclooxygenase inhibition.
What to do
Advise avoiding danshen during NSAID therapy, especially if the patient takes anticoagulants. Monitor for bleeding and bruising.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Danshen with Sulindac?
MediHelp rates the interaction as moderate. Danshen and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danshen (Salvia miltiorrhiza) has antiplatelet activity and has been reported to potentiate warfarin. With an NSAID there may be an additive bleeding tendency.
How serious is the interaction between Danshen and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding danshen during NSAID therapy, especially if the patient takes anticoagulants. Monitor for bleeding and bruising.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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