Drug interactions
Dapagliflozin + Glimepiride-pioglitazone
Severity: Moderate
Dapagliflozin and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin added to a sulfonylurea such as glimepiride raises the risk of hypoglycemia. Pioglitazone contributes further glucose lowering.
What this interaction means in plain words
Dapagliflozin and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Additive glucose-lowering through insulin-independent urinary glucose excretion plus sulfonylurea-driven insulin secretion.
What to do
Consider reducing the glimepiride dose when dapagliflozin is added and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
- Dapagliflozin + Glyburide Moderate
Frequently asked questions
Can I take Dapagliflozin with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Dapagliflozin and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to a sulfonylurea such as glimepiride raises the risk of hypoglycemia. Pioglitazone contributes further glucose lowering.
How serious is the interaction between Dapagliflozin and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glimepiride dose when dapagliflozin is added and monitor blood glucose.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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