Drug interactions
Chlorpropamide + Dapagliflozin
Severity: Moderate
Chlorpropamide and Dapagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin added to chlorpropamide increases hypoglycemia risk. Chlorpropamide's long duration of action may make hypoglycemia prolonged.
What this interaction means in plain words
Chlorpropamide and Dapagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Dapagliflozin belongs to Endocrine.
Why it happens
Additive glucose lowering from sulfonylurea-stimulated insulin secretion and SGLT2-mediated glucosuria.
What to do
Consider reducing the chlorpropamide dose when starting dapagliflozin and monitor blood glucose closely, especially in older or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Dapagliflozin
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
- Dapagliflozin + Glyburide Moderate
Frequently asked questions
Can I take Chlorpropamide with Dapagliflozin?
MediHelp rates the interaction as moderate. Chlorpropamide and Dapagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to chlorpropamide increases hypoglycemia risk. Chlorpropamide's long duration of action may make hypoglycemia prolonged.
How serious is the interaction between Chlorpropamide and Dapagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the chlorpropamide dose when starting dapagliflozin and monitor blood glucose closely, especially in older or renally impaired patients.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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