Drug interactions
Dapagliflozin-metformin + Dichlorphenamide
Severity: Moderate
Dapagliflozin-metformin and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes hyperchloremic metabolic acidosis. Combined with metformin, which carries a risk of lactic acidosis, acid-base disturbance may be worsened.
What this interaction means in plain words
Dapagliflozin-metformin and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive metabolic acidosis from carbonic anhydrase inhibition (bicarbonate loss) and metformin-related lactate accumulation.
What to do
Monitor serum bicarbonate and electrolytes regularly, and consider stopping or reducing therapy if persistent acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dapagliflozin-metformin with Dichlorphenamide?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes hyperchloremic metabolic acidosis. Combined with metformin, which carries a risk of lactic acidosis, acid-base disturbance may be worsened.
How serious is the interaction between Dapagliflozin-metformin and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate and electrolytes regularly, and consider stopping or reducing therapy if persistent acidosis develops.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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