Drug interactions
Dapagliflozin-metformin + Dienogest / estradiol valerate
Severity: Minor
Dapagliflozin-metformin and Dienogest / estradiol valerate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen and progestin combinations can reduce glucose tolerance and insulin sensitivity in some patients, slightly weakening glycemic control. The effect is usually modest.
What this interaction means in plain words
Dapagliflozin-metformin and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Sex steroids can reduce peripheral insulin sensitivity, producing pharmacodynamic antagonism of antidiabetic drugs.
What to do
Monitor blood glucose when hormonal therapy is started, changed or stopped. Adjust antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Dienogest / estradiol valerate?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Dienogest / estradiol valerate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogen and progestin combinations can reduce glucose tolerance and insulin sensitivity in some patients, slightly weakening glycemic control. The effect is usually modest.
How serious is the interaction between Dapagliflozin-metformin and Dienogest / estradiol valerate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when hormonal therapy is started, changed or stopped. Adjust antidiabetic doses if needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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