Drug interactions
Dapagliflozin-metformin + Diltiazem
Severity: Minor
Dapagliflozin-metformin and Diltiazem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may modestly increase blood glucose or reduce the response to antidiabetic drugs in some patients. It may also increase metformin exposure by transporter inhibition, though the clinical effect is generally small.
What this interaction means in plain words
Dapagliflozin-metformin and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Diltiazem belongs to Cardiovascular.
Why it happens
Possible calcium-channel-related reduction in insulin release and possible OCT inhibition; mechanism not firmly established.
What to do
Monitor blood glucose when starting or stopping diltiazem and adjust antidiabetic therapy if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Diltiazem?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diltiazem may modestly increase blood glucose or reduce the response to antidiabetic drugs in some patients. It may also increase metformin exposure by transporter inhibition, though the clinical effect is generally small.
How serious is the interaction between Dapagliflozin-metformin and Diltiazem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping diltiazem and adjust antidiabetic therapy if control changes.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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