Drug interactions
Dapagliflozin-metformin + Enalapril
Severity: Moderate
Dapagliflozin-metformin and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They may also reduce renal function in volume-depleted patients, and together with dapagliflozin's diuretic effect this can raise the risk of acute kidney injury and metformin accumulation with lactic acidosis.
What this interaction means in plain words
Dapagliflozin-metformin and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Enalapril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on glucose lowering and on renal hemodynamics, with reduced renal function possibly decreasing metformin clearance.
What to do
Monitor blood glucose, renal function and volume status when starting or adjusting enalapril, and hold metformin if acute kidney injury or dehydration develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Enalapril?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They may also reduce renal function in volume-depleted patients, and together with dapagliflozin's diuretic effect this can raise the risk of acute kidney injury and metformin accumulation with lactic acidosis.
How serious is the interaction between Dapagliflozin-metformin and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, renal function and volume status when starting or adjusting enalapril, and hold metformin if acute kidney injury or dehydration develops.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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