Drug interactions
Dapagliflozin-metformin + Fleroxacin
Severity: Moderate
Dapagliflozin-metformin and Fleroxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia, especially in patients with diabetes taking glucose-lowering drugs. Glycemic control may become unstable during treatment.
What this interaction means in plain words
Dapagliflozin-metformin and Fleroxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluoroquinolones affect pancreatic beta-cell insulin release, causing dysglycemia.
What to do
Monitor blood glucose closely during the antibiotic course and educate the patient on symptoms of hypo- and hyperglycemia. Change the antibiotic if dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Fleroxacin?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Fleroxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia, especially in patients with diabetes taking glucose-lowering drugs. Glycemic control may become unstable during treatment.
How serious is the interaction between Dapagliflozin-metformin and Fleroxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and educate the patient on symptoms of hypo- and hyperglycemia. Change the antibiotic if dysglycemia occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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