Drug interactions
Dapagliflozin-metformin + Fosphenytoin
Severity: Moderate
Dapagliflozin-metformin and Fosphenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin, the active form of fosphenytoin, can raise blood glucose by inhibiting insulin release, which may reduce glycemic control. Stopping it may unmask hypoglycemia.
What this interaction means in plain words
Dapagliflozin-metformin and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Fosphenytoin belongs to Central Nervous System.
Why it happens
Phenytoin inhibits pancreatic insulin secretion, opposing the antidiabetic drugs.
What to do
Monitor blood glucose when fosphenytoin is started, changed or stopped. Adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dapagliflozin-metformin and Fosphenytoin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dapagliflozin-metformin
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Fosphenytoin?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin, the active form of fosphenytoin, can raise blood glucose by inhibiting insulin release, which may reduce glycemic control. Stopping it may unmask hypoglycemia.
How serious is the interaction between Dapagliflozin-metformin and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fosphenytoin is started, changed or stopped. Adjust antidiabetic doses accordingly.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
