Drug interactions
Dapagliflozin-metformin + Gymnema
Severity: Moderate
Dapagliflozin-metformin and Gymnema: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gymnema sylvestre has been reported to lower blood glucose and may increase insulin secretion or reduce intestinal glucose absorption. Combined with antidiabetic drugs it may add to glucose lowering, and hypoglycemia is possible though uncommon with metformin and dapagliflozin.
What this interaction means in plain words
Dapagliflozin-metformin and Gymnema can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering effect through enhanced insulin secretion and reduced glucose absorption.
What to do
Monitor blood glucose closely if the patient uses gymnema and reduce antidiabetic doses if glucose falls; consider avoiding the herb.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Gymnema?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Gymnema can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gymnema sylvestre has been reported to lower blood glucose and may increase insulin secretion or reduce intestinal glucose absorption. Combined with antidiabetic drugs it may add to glucose lowering, and hypoglycemia is possible though uncommon with metformin and dapagliflozin.
How serious is the interaction between Dapagliflozin-metformin and Gymnema?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely if the patient uses gymnema and reduce antidiabetic doses if glucose falls; consider avoiding the herb.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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