Drug interactions
Dapagliflozin-metformin + Hydrocortisone
Severity: Moderate
Dapagliflozin-metformin and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic hydrocortisone can raise blood glucose and reduce the effectiveness of metformin and dapagliflozin. The effect depends on dose and duration.
What this interaction means in plain words
Dapagliflozin-metformin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Hydrocortisone belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and induce peripheral insulin resistance, opposing the glucose-lowering effect.
What to do
Monitor blood glucose during systemic corticosteroid therapy and adjust antidiabetic doses; reassess when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Hydrocortisone?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic hydrocortisone can raise blood glucose and reduce the effectiveness of metformin and dapagliflozin. The effect depends on dose and duration.
How serious is the interaction between Dapagliflozin-metformin and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during systemic corticosteroid therapy and adjust antidiabetic doses; reassess when the steroid is tapered.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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