Drug interactions
Dapagliflozin-metformin + Hydroxyprogesterone caproate
Severity: Minor
Dapagliflozin-metformin and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can modestly reduce glucose tolerance, but hydroxyprogesterone caproate rarely has a clinically important effect on glycemic control in diabetic patients.
What this interaction means in plain words
Dapagliflozin-metformin and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progestogens may reduce insulin sensitivity, giving a weak pharmacodynamic opposition to the antidiabetic drugs.
What to do
Monitor blood glucose when therapy is started or stopped. Adjust antidiabetic doses only if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can modestly reduce glucose tolerance, but hydroxyprogesterone caproate rarely has a clinically important effect on glycemic control in diabetic patients.
How serious is the interaction between Dapagliflozin-metformin and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when therapy is started or stopped. Adjust antidiabetic doses only if control changes.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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