Drug interactions
Dapagliflozin-metformin + Ibuprofen / famotidine
Severity: Moderate
Dapagliflozin-metformin and Ibuprofen / famotidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine is a cationic drug secreted by renal tubular transporters and may modestly compete with metformin for elimination. NSAIDs such as ibuprofen can also reduce renal function, particularly with dehydration, which may raise metformin exposure. Dapagliflozin adds volume depletion risk, so the renal effects may be additive.
What this interaction means in plain words
Dapagliflozin-metformin and Ibuprofen / famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular cation transport (famotidine) and NSAID-related reduction in renal perfusion decrease metformin clearance.
What to do
Monitor renal function and hydration status, particularly with chronic or high-dose NSAID use, and review metformin dose if eGFR declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Ibuprofen / famotidine?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Ibuprofen / famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Famotidine is a cationic drug secreted by renal tubular transporters and may modestly compete with metformin for elimination. NSAIDs such as ibuprofen can also reduce renal function, particularly with dehydration, which may raise metformin exposure. Dapagliflozin adds volume depletion risk, so the renal effects may be additive.
How serious is the interaction between Dapagliflozin-metformin and Ibuprofen / famotidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hydration status, particularly with chronic or high-dose NSAID use, and review metformin dose if eGFR declines.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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