Drug interactions
Dapagliflozin-metformin + Indapamide
Severity: Minor
Dapagliflozin-metformin and Indapamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide, a thiazide-like diuretic, may modestly raise blood glucose, though it is considered relatively metabolically neutral at low doses. Additive diuresis with dapagliflozin may cause volume depletion.
What this interaction means in plain words
Dapagliflozin-metformin and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Indapamide belongs to Cardiovascular.
Why it happens
Thiazide-like diuretics can cause hypokalemia and insulin resistance, and additive diuresis occurs with SGLT2 inhibition.
What to do
Monitor blood glucose, blood pressure and electrolytes, and adjust therapy if control worsens or volume depletion develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Indapamide
Frequently asked questions
Can I take Dapagliflozin-metformin with Indapamide?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide, a thiazide-like diuretic, may modestly raise blood glucose, though it is considered relatively metabolically neutral at low doses. Additive diuresis with dapagliflozin may cause volume depletion.
How serious is the interaction between Dapagliflozin-metformin and Indapamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure and electrolytes, and adjust therapy if control worsens or volume depletion develops.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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