Drug interactions
Dapagliflozin-metformin + Insulin lispro protamine / insulin lispro
Severity: Moderate
Dapagliflozin-metformin and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining dapagliflozin and metformin with a premixed lispro insulin adds glucose-lowering effects and raises the risk of hypoglycemia. The risk is greatest when the oral agents are started or the insulin dose is not reduced.
What this interaction means in plain words
Dapagliflozin-metformin and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose lowering through insulin-dependent and insulin-independent pathways.
What to do
Monitor blood glucose closely when starting the combination and consider lowering the insulin dose to avoid hypoglycemia. Reassess insulin requirements if either oral agent is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining dapagliflozin and metformin with a premixed lispro insulin adds glucose-lowering effects and raises the risk of hypoglycemia. The risk is greatest when the oral agents are started or the insulin dose is not reduced.
How serious is the interaction between Dapagliflozin-metformin and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting the combination and consider lowering the insulin dose to avoid hypoglycemia. Reassess insulin requirements if either oral agent is stopped.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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