Drug interactions
Dapagliflozin-metformin + Insulin regular human
Severity: Moderate
Dapagliflozin-metformin and Insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular insulin used with dapagliflozin and metformin has additive glucose-lowering effects, which can lead to hypoglycemia. A lower insulin dose is often needed when the oral agents are added.
What this interaction means in plain words
Dapagliflozin-metformin and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose lowering via insulin action, urinary glucose excretion and decreased hepatic gluconeogenesis.
What to do
Consider reducing the insulin dose when starting dapagliflozin-metformin and monitor blood glucose closely. Adjust doses again if either agent is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Insulin regular human?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular insulin used with dapagliflozin and metformin has additive glucose-lowering effects, which can lead to hypoglycemia. A lower insulin dose is often needed when the oral agents are added.
How serious is the interaction between Dapagliflozin-metformin and Insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting dapagliflozin-metformin and monitor blood glucose closely. Adjust doses again if either agent is withdrawn.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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