Drug interactions
Dapagliflozin-metformin + Isoniazid
Severity: Moderate
Dapagliflozin-metformin and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can impair glucose tolerance and cause hyperglycemia in some patients, which may reduce the effect of antidiabetic therapy. Tuberculosis itself also complicates glycemic control.
What this interaction means in plain words
Dapagliflozin-metformin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Isoniazid belongs to Anti Bacterial.
Why it happens
Mechanism is not firmly established; isoniazid may impair carbohydrate metabolism and glucose tolerance.
What to do
Monitor blood glucose regularly during isoniazid therapy and adjust antidiabetic treatment if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Isoniazid
Frequently asked questions
Can I take Dapagliflozin-metformin with Isoniazid?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid can impair glucose tolerance and cause hyperglycemia in some patients, which may reduce the effect of antidiabetic therapy. Tuberculosis itself also complicates glycemic control.
How serious is the interaction between Dapagliflozin-metformin and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly during isoniazid therapy and adjust antidiabetic treatment if control deteriorates.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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