Drug interactions
Dapagliflozin-metformin + Liotrix
Severity: Moderate
Dapagliflozin-metformin and Liotrix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liotrix contains levothyroxine and liothyronine, and thyroid replacement can raise glucose and increase antidiabetic requirements. Control may worsen after initiation or dose increases.
What this interaction means in plain words
Dapagliflozin-metformin and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormone increases hepatic glucose output and metabolic rate, opposing glucose-lowering drugs.
What to do
Monitor glucose when starting or changing liotrix and adjust antidiabetic therapy accordingly. Watch for hypoglycemia if the thyroid dose is lowered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Liotrix?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liotrix contains levothyroxine and liothyronine, and thyroid replacement can raise glucose and increase antidiabetic requirements. Control may worsen after initiation or dose increases.
How serious is the interaction between Dapagliflozin-metformin and Liotrix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or changing liotrix and adjust antidiabetic therapy accordingly. Watch for hypoglycemia if the thyroid dose is lowered.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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